Thesis Functional Responses of Cardiac and Skeletal Muscle Mitochondria to Short-term Obesity: Are All Obesities the Same?
نویسندگان
چکیده
.................................................................................................................................. ii TABLE OF CONTENTS ............................................................................................................ iv INTRODUCTION ........................................................................................................................ 1 LITERATURE REVIEW ............................................................................................................ 7 Basic Physiology ........................................................................................................................ 7 Metabolism in the Normal Heart ............................................................................................ 7 Metabolism in Normal Skeletal Muscle .................................................................................. 8 Fatty Acid Oxidation FA Use.................................................................................................. 8 Glucose Use ............................................................................................................................ 9 The TCA Cycle, Electron Transfer System, and Mitochondrial Respiration.......................... 9 Mitochondria and Obesity ..................................................................................................... 11 Skeletal Muscle Mitochondrial Responses to Obesity and DM ............................................ 13 Obesity and Metabolism in Hibernating Mammals ............................................................ 15 METHODS .................................................................................................................................. 17 Ethical Approval ..................................................................................................................... 17 Ground Squirrels .................................................................................................................... 17 Mice .......................................................................................................................................... 18 Glucose Tolerance Tests ......................................................................................................... 18 Preparation of Isolated Skeletal and Cardiac Muscle Mitochondria ................................ 18 Saponin Permeabilized Soleus Muscle .................................................................................. 19
منابع مشابه
Responses of Muscle Mitochondrial Function to Physical Activity: A Literature Review
Skeletal muscles play an active role in regulating the metabolic homeostasis through their ability for relating to adipose tissue and endocrine hormones. Contraction of the skeletal muscle leads to increased release of several myokines, such as irisin, which is able to interact with the adipose tissue. Physical activity promotes the irisin mechanism by augmenting the peroxisomes (PGC1-α) in the...
متن کاملEffect of 12-Weeks Elastic-Band Resistance Training on Functional and Obesity Indices in Osteosarcopenic Obese Elderly Women
Osteosarcopenic obesity is the result of processes that lead to muscle and bone breakdown and increased fat tissue. The purpose of this study was to investigate the effect of 12 weeks elastic band resistance training on functional indicators and Osteosarcopenic obesity index in women with Osteosarcopenic obesity. In this single blind randomized clinical trial, 49 elderly women with age 64.13 ± ...
متن کاملNeuregulins Response to Exercise: a Mini Review
The Neuregulin is a member of the epidermal growth factors (EGF) family of receptor kinases, was originally identified as the product of the transforming gene derived from chemically induced rat neuroblastoms. A variety of different protein isoforms are produced from single Neuregulin gene. Four distinct vertebrate gene encode Neuregulin, prosaically named NRG1, NRG2, NRG3, and NRG4. Most of bi...
متن کاملOne-year high fat diet affects muscle-but not brain mitochondria
It is well known that few weeks of high fat (HF) diet may induce metabolic disturbances and mitochondrial dysfunction in skeletal muscle. However, little is known about the effects of long-term HF exposure and effects on brain mitochondria are unknown. Wistar rats were fed either chow (13E% fat) or HF diet (60E% fat) for 1 year. The HF animals developed obesity, dyslipidemia, insulin resistance...
متن کاملInjury to skeletal muscle of mice following acute and sub-acute pregabalin exposure
Objective(s): Pregabalin (PGB) is a new antiepileptic drug that has received FDA approval for patient who suffers from central neuropathic pain, partial seizures, generalized anxiety disorder, fibromyalgia and sleep disorders. This study was undertaken to evaluate the possible adverse effects of PGB on the muscular system of mice. Materials and Methods: To evaluate the effect of PGB on skeletal...
متن کامل